"Drive" was The Cars' highest charting single in the United States, peaking at #3 on the Billboard Hot 100 chart. On the Adult Contemporary chart, the song went all the way to #1. It also got to #5 in the UK singles chart, becoming their second biggest UK hit, then was re-released in the UK in 1985 (after the Live Aid performance at Wembley Stadium), this time charting at #4. The song was also a big hit in what was West Germany, reaching #4, and in Canada, reaching #6. In addition, it was famously used as part of the Live Aid concert in 1985, as the background music to a montage of clips showing poverty-stricken Africa. The song is about drug abuse.
The music video for the song stars, besides Ocasek and Orr, Czech-born supermodelPaulina Porizkova, who later married Ocasek. The video was directed by actor Timothy Hutton.
Jars of Clay recorded a cover of the song during the recording sessions for their 2006 release Good Monsters, but it did not make the final track listing. However, the song was released on a Nettwerk-released promo disc entitled Reel To Reel, Volume 3.4. The band has stated that the cover will be released officially on an upcoming release in 2008.
The Canadian teen drama Degrassi: The Next Generation, which was notable for naming each episode after a hit song from the 1980s, named an episode after this song.
The song appeared in the film 50 First Dates during the scene where Henry Roth (Adam Sandler) is driving after Lucy Whitmore (Drew Barrymore) has broken up with him, feeling that she is keeping him from living his life fully, and has burnt all her journal entries about him so that her memory of him will be gone for good.
The song appeared in the live action film Transformers, during the scene where Bumblebee plays the theme to encourage Sam Witwicky (Shia LaBeouf) to give his love interest, Mikaela Banes (Megan Fox), a ride home. Particularly the portion of the song that says; "who's gonna drive you home, tonight?".
A short excerpt of the song was played at the Dior Couture fashion show.