CXADR

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Coxsackie virus and adenovirus receptor
PDB rendering based on 1eaj.
Available structures: 1eaj, 1f5w, 1jew, 1kac, 1p69, 1p6a, 1rsf, 2j12, 2j1k, 2npl
Identifiers
Symbols CXADR; CAR; HCAR
External IDs OMIM: 602621 MGI: 1201679 HomoloGene: 1024
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1525 13052
Ensembl ENSG00000154639 ENSMUSG00000022865
Uniprot P78310 Q3TV22
Refseq NM_001338 (mRNA)
NP_001329 (protein)		 NM_001025192 (mRNA)
NP_001020363 (protein)
Location Chr 21: 17.81 - 17.86 Mb Chr 16: 78.18 - 78.22 Mb
Pubmed search [1] [2]

Coxsackie virus and adenovirus receptor, also known as CXADR, is a human gene.[1]

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.[1]

References

  1. ^ a b "Entrez Gene: CXADR coxsackie virus and adenovirus receptor".

Further reading

  • Carson SD (2002). "Receptor for the group B coxsackieviruses and adenoviruses: CAR.". Rev. Med. Virol. 11 (4): 219–26. PMID 11479928. 
  • Selinka HC, Wolde A, Sauter M, et al. (2004). "Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism.". Med. Microbiol. Immunol. 193 (2-3): 127–31. doi:10.1007/s00430-003-0193-y. PMID 12920584. 
  • Bergelson JM, Cunningham JA, Droguett G, et al. (1997). "Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.". Science 275 (5304): 1320–3. PMID 9036860. 
  • Tomko RP, Xu R, Philipson L (1997). "HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3352–6. PMID 9096397. 
  • Carson SD, Chapman NN, Tracy SM (1997). "Purification of the putative coxsackievirus B receptor from HeLa cells.". Biochem. Biophys. Res. Commun. 233 (2): 325–8. doi:10.1006/bbrc.1997.6449. PMID 9144533. 
  • Bergelson JM, Krithivas A, Celi L, et al. (1998). "The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses.". J. Virol. 72 (1): 415–9. PMID 9420240. 
  • Fechner H, Haack A, Wang H, et al. (2000). "Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers.". Gene Ther. 6 (9): 1520–35. doi:10.1038/sj.gt.3301030. PMID 10490761. 
  • Bowles KR, Gibson J, Wu J, et al. (1999). "Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor gene.". Hum. Genet. 105 (4): 354–9. PMID 10543405. 
  • Bewley MC, Springer K, Zhang YB, et al. (1999). "Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR.". Science 286 (5444): 1579–83. PMID 10567268. 
  • Tomko RP, Johansson CB, Totrov M, et al. (2000). "Expression of the adenovirus receptor and its interaction with the fiber knob.". Exp. Cell Res. 255 (1): 47–55. doi:10.1006/excr.1999.4761. PMID 10666333. 
  • van Raaij MJ, Chouin E, van der Zandt H, et al. (2001). "Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution.". Structure 8 (11): 1147–55. PMID 11080637. 
  • Cohen CJ, Gaetz J, Ohman T, Bergelson JM (2001). "Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting.". J. Biol. Chem. 276 (27): 25392–8. doi:10.1074/jbc.M009531200. PMID 11316797. 
  • Noutsias M, Fechner H, de Jonge H, et al. (2001). "Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections.". Circulation 104 (3): 275–80. PMID 11457744. 
  • Thoelen I, Magnusson C, Tågerud S, et al. (2001). "Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene.". Biochem. Biophys. Res. Commun. 287 (1): 216–22. doi:10.1006/bbrc.2001.5535. PMID 11549277. 
  • He Y, Chipman PR, Howitt J, et al. (2001). "Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor.". Nat. Struct. Biol. 8 (10): 874–8. doi:10.1038/nsb1001-874. PMID 11573093. 
  • Cohen CJ, Shieh JT, Pickles RJ, et al. (2002). "The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15191–6. doi:10.1073/pnas.261452898. PMID 11734628. 
  • Law LK, Davidson BL (2002). "Adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor.". J. Virol. 76 (2): 656–61. PMID 11752156. 
  • van't Hof W, Crystal RG (2002). "Fatty acid modification of the coxsackievirus and adenovirus receptor.". J. Virol. 76 (12): 6382–6. PMID 12021372. 
  • Walters RW, Freimuth P, Moninger TO, et al. (2002). "Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape.". Cell 110 (6): 789–99. PMID 12297051. 
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